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KMID : 1037120170350010043
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The World Journal of Men′s Health
2017 Volume.35 No. 1 p.43 ~ p.50
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Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model
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Moon Hyong-Woo
Park Jung-Woo
Lee Kyu-Won
Jeong Hyun-Cheol
Choi Jin-Bong
Choi Sae-Woong
Bae Woong-Jin
Cho Hyuk-Jin
Ha Im-Ui-Syn
Hong Sung-Hoo
Geum Jeong-Ho
Hong Seong-Bin
Kim Sae-Woong
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Abstract
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Purpose: This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats.
Materials and Methods: Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined.
Results: Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis.
Conclusions: Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
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KEYWORD
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Antioxidants, Erectile dysfunction, Testosterone
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